On a bicycle trip across the country, a young Neill Kirby McMillan Jr. experiences The Mojo Revelation and becomes Mojo Nixon. After teaming up with the enigmatic Skid Roper, he unexpectedly finds mainstream success during the Golden Age of MTV.

Eighteen years in the making, two-headed cow started off as a black and white film that followed Dexter Romweber and his drummer Crow on a rock and roll tour along the same route as General Sherman. The film was not finished due to many circumstances, but the filmmakers were able to resume the film seventeen years later. After major TV appearances, a stint on a major label, bouts of depression and drug addiction, the film took on a different tone and poignancy.