Twenty-eight weeks after the spread of a deadly rage virus, the inhabitants of the British Isles have lost their battle against the onslaught, as the virus has killed everyone there. Six months later, a group of Americans dare to set foot on the Isles, convinced the danger has passed. But it soon becomes all too clear that the scourge continues to live, waiting to pounce on its next victims.

A camping trip seems like the perfect way for a group of friends to spend a vacation they will never forget. Unfortunately, no one will be left alive to remember the trip! Something lurks in these barren woods, something more insane than a chainsaw-wielding psycho, something more brutal than machete swinging mama's boy and more savage than a tribe of flesh-eating cannibals. There's a LOONY loose!