After returning home from her most recent runaway trip, Myca isn't quite the same. The brash rock n' roll drummer's strange behavior is most evident to her foster sister and bandmate, Devin. Following a horrific episode at one of the sisters' concerts, Devin discovers the source behind Myca's new demeanor: an insatiable thirst for human blood.

Sam, an affable, yet oblivious father, finds out his daughter is gay a week before she is to get married, and while trying to come to terms with his feelings, he encounters his straight-laced future in-laws.

Two blood-soaked ladies of the night must navigate their way to safety while being pursued by a murderous family of psychopathic inbreds with a score to settle. With the help of a slick bionic pimp named Silky, they will prove that love can overcome shame, and there are few things fiercer than a whore scorned.