There are four ancient Beauties: a female warrior Liu Rusi, a sentimental winebibber Chen Zilian, a startling geisha Li Mengying and a prodigal daughter Susu. Their souls were carried to modern society by a mystery necklace, and entered a girl Qin Duyi's body who is ordinary and hapless. The only way to send the four ancient beauties back, is to get the real love of four heartless men.

At the end of the Ming dynasty, the Tian family’s pharmacy in Jianchang Prefecture suffers repeated attacks from bandits. Tian Chongming and Zhou Tianyin risk their lives to rescue the medicines, but tragedy strikes when the drugs cause the deaths of soldiers. The Tian family faces a death sentence, and the shocking truth emerges — the mastermind behind it all is Zhou Tianyin’s own father, Zhou Wanting. Once exposed and executed, his betrayal leaves the two sworn brothers divided by loyalty, guilt, and a blood feud that neither can escape.