Claire of the Moon is set in the 1990s in the Pacific Northwest. Claire Jabrowski, a famous heterosexual author, decides to attend a retreat for all-female writers. Claire's rommate at the retreat is Dr. Noel Benedict, author of a book called The Naked Truth. The movie culminates in a sexual encounter between the two authors.

A family struggles to stay together after a series of tragedies threatens to tear them apart.