When a sheriff arrests a writer, a family, a couple, and a hitchiker and throws them in a jail cell in the deserted town of Desperation, they must fight for their lives.

The human race is threatened by a powerful creature, and only the combined power of Superman, Batman, Wonder Woman, Green Lantern, Martian Manhunter and The Flash can stop it. But can they overcome their differences to thwart this enemy using the combined strength of their newly formed Justice League?