“Sisid” is the story of a videographer, played by Raymond Bagatsing, who was betrayed by women in the past and swears never to be betrayed again. He meets a nightclub performer played by de Rossi. The two have an affair, perhaps even fall in love, but Bagatsing hesitates to commit himself to her. De Rossi tells Bagatsing the story of one of her lovers, played by Rodel Velayo; Velayo was once chauffeur to the beautiful but spoiled daughter (again, de Rossi) of a wealthy fishpond operator. De Rossi is kidnapped, Velayo helps her escape; when she learns of his involvement in the plot, she leaves him. Velayo wanders about, until he meets de Rossi in the nightclub; he insists that nightclub de Rossi is really his long-lost de Rossi, and pursues her with fierce intensity. Bagatsing feels threatened by Velayo’s presence, even jealous, and the two struggle over the woman they both think they love.

Annie, an alluring lady, catches the eye of old widower Leoncio. The old man marries her after a short period of acquaintance. Leoncio's son Robert and daughter Marites disapprove of their father's single-handed decision, leading to a conflict that causes the old man's fatal heart attack. After Leoncio's death, Robert feels terribly sorry for Annie especially when he discovers that she is suffering from schizophrenia. Soon, Annie's condition helps Leoncio's children realize the essence of a family.