Hit by the realization that his hustle is taking him nowhere, Johnny is on the verge of giving up boxing when nurse Ava gives him a much-needed nudge into trying again.

Celestine gets hooked on a new dangerous drug, Nepenthe, and is visited by a mysterious woman named Irene who subtly pushes her towards madness. Meanwhile, Bob and his friends try to save Celestine from her newfound insanity.