Led by Captain Christopher Pike, the crew of the starship Enterprise investigates of a far-off planet which was the site of a shipwreck eighteen years earlier. They encounter telepathic aliens who seek a human male specimen for their menagerie.

Gangland boss Joe Kalhari, working with Ricki Hart, operator of a swamp-side dive in the Okefenokee swamp aside the Georgia-Florida border, rules an empire of smugglers who run dope and undesirable aliens into the United States, uses seaplanes at the primary mode of transportation. Searching for his sweetheart,Lowheeya, who has been lured into the shack of Pully, a Kalhari henchman, airplane pilot Chick Osceola, finds evidence of the smuggling operation.

A stage headed West with a group of passengers is attacked by Cheyenne Indians, and takes refuge in a nearby ghost town.

After several locals are viciously murdered, a Louisiana sheriff starts to suspect he may be dealing with a werewolf.