Marie is juggling a demanding job as a doctor in oncology and her hectic family life. When she finds out she's pregnant with her third child, she handles it with her customary efficiency. But the stress is more than she bargained for, driving Marie to decisions she might live to regret.

Denmark, 2013. Police officers Carl Mørck and Hafez el-Assad, sole members of Department Q, which is focused on closing cold cases, investigate the disappearance of politician Merete Lynggaard, vanished when she and her brother were traveling aboard a ferry five years ago.