Depression-era bank robber John Dillinger's charm and audacity endear him to much of America's downtrodden public, but he's also a thorn in the side of J. Edgar Hoover and the fledgling FBI. Desperate to capture the elusive outlaw, Hoover makes Dillinger his first Public Enemy Number One and assigns his top agent, Melvin Purvis, the task of bringing him in dead or alive.

A grieving mother transforms herself into a vigilante following the murders of her husband and daughter, eluding the authorities to deliver her own personal brand of justice.

Jim Hanson’s quiet life is suddenly disturbed by two people crossing the US/Mexico border – a woman and her young son – desperate to flee a Mexican cartel. After a shootout leaves the mother dead, Jim becomes the boy’s reluctant defender. He embraces his role as Miguel’s protector and will stop at nothing to get him to safety, as they go on the run from the relentless assassins.

A series of interconnected short films are the backdrop for a maniac screenwriter who pitches insane storylines featuring some of Hollywood's biggest and brightest. In some countries, like the United Kingdom and the Netherlands, the structure differs. Instead of a pitch, the films are connected by a group of three teenagers searching for the most banned film in the world, Movie 43, which will ultimately lead to the destruction of civilization.