After getting fired from his teaching job and dumped by his girlfriend, Jack, a painter, embarks on a soul searching road trip with his dog, Scout. However, bad weather and bumps in the road quickly cause more problems than he can handle. An impulsive decision to take from a bag full of unknown pills leads him on a drug-fueled journey with no destination in sight, and he soon finds himself making both friends and foes along the way.

Three friends, one of whom is visually impaired and has a miniature guide horse named Carmine, set off to find Carmine a very special pair of sneakers for a very special occasion.