To celebrate the 100th birthday of America's most audacious writer, William S. Burroughs, Chicago Humanities Festival brings together a motley crew of poets, writers, and musicians. William Seward Burroughs (1914 - 1997) was an American writer and visual artist. He was a primary figure of the Beat Generation and a major postmodernist author whose influence is considered to have affected a range of popular culture as well as literature. Burroughs's needs took him across the United States, down into Mexico, to Europe and beyond. On his travels, he meets up with various members of the underground drug and "outcast" cultures.

Sending a burning arrow into the stunting effects that the compartmentalization of culture has on how creativity manifests, visual artist Doug Aitken embarked on an experiment exploring a less materialistic and more nomadic direction of art creation, exhibition, and participation. Station to Station involved a train that crossed North America housing a constantly changing creative community including artists, musicians, and curators, who collaborated in the creation of recordings, artworks, films, and 10 unique happenings, across the country.