Marie, together with her mother Carla and grandma Ruth, runs a family-owned hotel on the Staffelsee. However, as Ruth fears that her granddaughter, who prefers to change her car tires rather than make herself beautiful in front of the mirror, gets drowsy at some point, she secretly makes a personal announcement in Marie's name. Without a photo of her beautiful granddaughter, nobody can even get married even in times of the internet. Ruth hires the professional photographer Niklas, who succeeds in the miracle: Marie is kissing awake. In the role of a modern Cinderella Mira Bartuschek discovers her femininity and Kai Schumann as her photographer the motif of his life.

Flo is not quite a normal teenager: While all his friends only think about sex he can't even pronounce the word "S - E - X". But everything changes completely when one morning Flo wakes up from a strange call. His penis, excited for the first time, begins to talk to him. He claims that Flo severely neglected him for 15 years and it's time to release him.

Miracle at St. Anna chronicles the story of four American soldiers who are members of the all-black 92nd "Buffalo Soldier" Division stationed in Tuscany, Italy during World War II.