Pennsylvania, 1956. Frank Sheeran, a war veteran of Irish origin who works as a truck driver, accidentally meets mobster Russell Bufalino. Once Frank becomes his trusted man, Bufalino sends him to Chicago with the task of helping Jimmy Hoffa, a powerful union leader related to organized crime, with whom Frank will maintain a close friendship for nearly twenty years.

A nameless man wanders the city, littered with necrotic artifacts and a trail of corpses. Are his grotesque hallucinations clues to a violent past?

A motivational speaker, plagued by an uncontrollable itch on her head, becomes infected with a parasitic demon from her homeland.