Luxury Hotel brings together four stories of hopelessness in the same hotel. Mehdi, who left behind a terrorist organization to pursue a new life; an Afghan family fleeing the Taliban; a young gay couple hoping to live their lives as they wish in the Istanbul of their dreams; and a young girl trapped in drug addiction. What begins as a stop filled with hope for them, this "Luxury Hotel," eventually becomes a limbo where they are trapped. No matter how much they flee, they may never truly escape their otherness. Yet they remain silent; we rarely hear them speak or react. There is a weariness over them, but it is clear they are screaming for help. Still, to hear their voices, perhaps we first need foresight.

Muna is the 6-year-old daughter of a Palestinian family, living in Gaza. In fall 2009, their house gets raided by Israeli soldiers. When she comes out of hiding, Muna realizes that she's all alone. Not knowing what to do, she wanders the streets of Gaza in search of her family. During her search Muna comes across to surgeon Ela who has travelled to Gaza with Doctors Worldwide in order to aid victims of war. With the help of her colleague Ali and his Gazan friend Süleyman, Ela tries to find Muna's family. In their quest, the doctors confront the harsh realities of war.