The tale of four "mummies", two vampires, and a collection of other monsters converge in a story spanning nearly 5000 years over four continents.

After winning an all-expenses-paid Mardis Gras vacation in New Orleans, a tight-knit group of college friends prepare for the time of their lives. But boobs, beads and debauchery get pushed to the back burner when murder bubbles up to the surface. A local tourist trap hawking voodoo trinkets seems to be the source of all the trouble, but no one's sure who's pulling the strings when it comes to orchestrating the killings.