Greg is married to Cindy-- the epitome of a successful woman. She seems to have everything in her life except for one thing—an, equally successful husband. Cindy decides to call it quits with Greg, demanding an annulment. Greg tries to prevent it from happening but to no avail, Cindy doesn’t want to hear any apology anymore. To clear his mind, Greg rides all the way to his cousin Gab’s resort in La Union. This is where he meets HYDES, a perky man-hating staff to which he had an unfortunate meetcute with, until their relationship deepens. It all felt real until Cindy shows up at the resort, asking Greg to give their marriage another chance. Whose heart will prevail in the end?

In a community by the railroad, an old healer named Tatang performs a “miracle” when a young male lover is run over by a train. It is said that Tatang can heal with poetry and his Muse. Another cataclysmic event will make the community discover the next healer by the railroad.

Valentin Roxas was raised by his Tatay Lito alone when his mother left them to work abroad when he was seven. To maintain a sense of normalcy, Lito wrote young Val letters supposedly from his mother, promising she would return.

The film portrays the true stories of Filipinos, who, due to poverty in their country, are forced to go abroad to look for work, hoping they would find a better life.

With detailed assistance from a self-help book -- written by a self-described love guru (Jolina Magdangal) -- Denise (Jennylyn Mercado), a hopeless romantic, finally manages to catch the attention of the man she's had her eye on forever (Mike Tan). But once she has what she thinks she wants, Denise begins to wonder whether she actually had Mr. Right all along -- her best friend, Caloy (Mark Herras), who's secretly in love with her.

"Puso 3" is a digital trilogy: "Lost and Found", "Siklo" and "Kulam". "Lost and Found," is an off-beat, out-of-the-ordinary story about a unique journey and surreal realizations. It's a quirky comedy about missing persons, "accepting the bizaare and discovering the nature of the people close to you during stressful moments." "Siklo," on the other hand, is an inspiring tale of optimism. It tackles domestic violence, with the victim joining a support group whose leader the victim becomes close to, sharing her heartaches and desires with her. A striking twist will make the victim realize that her life need not end in despair, knowing that after each love lost, life goes on. "Kulam," is a mystic and intriguing story about love and black magic.

In 1986, Estrell, an angry Marxist activist loved her country but hated God. That is why Estrell made sure that each of her 4th year high school students, including Bernard, would do the same.

Jewel is a mysterious woman who lives alone in the city. She has a secret which has led her to settle into a lonely existence. That is, until she meets Nico, a broken-hearted, down-and-out guy who also feels unlovable like she does. Jewel is torn between wanting to love him and wanting to save him from herself.

Enteng has made use of his skills in the ironworks and robotics industries, becoming a successful businessman. He also spends more time with his cute granchild Benokis. But trouble arises when Kwak-Kwak, who was booted from Engkatasya, returns to create chaos through a virtual game. Enteng then gathers the Abangers, led by his son Benok, to fight.

The story of Raffy and Gela who find themselves taking off for Palawan to escape the not so great realities of their current lives and catch up on their respective me-time. But as fate would have it, they find themselves meeting and enjoying each other's company.