Living in the lawless Ishinari District in a future Japan, sisters Ami (Hina Nagimiya) and Yoshie (Hanakage Kanon) who sold their bodies to help their parents, try to earn a living performing as an idol group in the area. When their performance causes stranger Matsukata (Tak Sakaguchi) a notorious hitman, to notice their condition, the three realize their worth to each other in the fight against Aoyama Dharma (Kimono Negishi), the female boss of a notorious organ harvesting ring in the area. Realizing that even their skills are no match for her army of goons and henchmen, the two are outfitted with special homemade weaponry to their bodies and become the ultimate killers.

Problems with the neighborhood? Grandmother Yang and her two slightly mentally challenged grandchildren solve them in their very own way. Her neighbor Kazuya not only has to take care of the clan's legacy, but also his disabled sister, and all of them have to deal with the Sea Snakes gang who wants to compete with the Yang family.

While fooling around with a self-made crossbow, Kira accidentally kills his classmate Itsuki. For lack of evidence, the young student is found innocent. However, his trial is widely covered by the mass media, and the following uproar from society won’t leave his family untouched.

After his devastatingly fast, samurai-style combat approach sets filmmakers against him, a legendary action star films his own movie—on turf claimed by feuding yakuza gangs, including Japan’s deadliest martial arts assassin.

Deep in the forest, as Sora is pressured to finish a high-paying kidnapping gig, a monstrous bear suddenly appears. A chaos-driven fight for survival erupts.