Escaping an abusive husband, Melissa takes her baby to a cabin in a small town. When the baby is abducted and the police are less than helpful, she takes matters into her own hands and discovers the dark secret the town is hiding.

Fleeing her past, a troubled hiker and her dog traverse the Appalachian Trail, only to fall under the spell of a dangerous man. As obsession and visions mount, she's drawn toward Mile 666, where lust, death, and something ancient await.