When an unknown disease wipes out most of the world’s population, a man with unique blood is isolated for study. Fearing for his wife’s safety, he breaks his quarantine – into a world overrun by monstrous Infected and a shadowy agency hunting them down.

Fyodor Karamazov is ill and holed up in his oceanfront home with his loyal caretaker Liz, when his three estranged children return home to settle a financial dispute. Despite carving out new lives for themselves—Aly has found refuge in religion, Viv is a queer artist, and Dmitri is a charismatic schemer—each is in the midst of their crisis. Their attempts at reconciliation are complicated further when Fyodor is murdered and they must finally face the truth about their dark past. Part murder mystery, part spiritual quest, The Karamazovs follows Liz, who pieces together memories of that eventful week.