Detectives Marcus Burnett and Mike Lowrey of the Miami Narcotics Task Force are tasked with stopping the flow of the drug Ecstasy into Miami. They track the drugs to the whacked-out Cuban drug lord Johnny Tapia, who is also involved in a bloody war with Russian and Haitian mobsters. If that isn't bad enough, there's tension between the two detectives when Marcus discovers that playboy Mike is secretly romancing Marcus’ sister, Syd.

An LA detective is murdered because she has microfilm with the recipe to make cocaine cookies. Two cops partner to find and stop the fiends before they can dope the nation by distributing their wares via the 'Wilderness Girls' cookie drive.