After his vampire boss snacks on a few employees, a hapless accountant learns that monsters are real, hungry and of course, looking for him. As he struggles to avoid his own untimely end, the fate of the world rests in his hands.

When a U.S. congressman's daughter passing through a small town in Mississippi dies in a mysterious triple homicide, a team of F.B.I. agents descends to investigate, the team's brilliant but jaded lead agent battling demons both past and present, as his beautiful, tough-as-nails partner tries to hold him and the case together. They find a struggling and corrupt sheriff's department, a shadowy and much-feared figure, who seems to be pulling all of the town's strings from his mansion on the edge of town and a local victim with a strange connection to a number of the town's most prominent figures.

Two bungling robbers try to play doctors at a 24hr. clinic while they wait for the time lock safe to open and have to treat the crazies that come out after midnight.