There are essentially five cons that are the basis for every swindle since the dawn of man; today's Nigerian email scam is nothing more than a derivation of a Spanish conquistador's bait-and-switch con that started more than 600 years ago. In Scammed, Paul Wilson, dubbed the "World's Greatest Con Man," and his team take a detailed look inside the complicated schemes and micro-cons that have plagued unsuspecting people for hundreds, even thousands of years, showing how many of these scams not only survived but evolved to be brutally effective with the help of modern technology. In each episode, Paul plays out long cons on designated marks so that he can help expose the cons, hustles and schemes that have victimized so many people, while teaching others how to avoid them.

As one of the youngest Planned Parenthood clinic directors in the nation, Abby Johnson was involved in upwards of 22,000 abortions and counseled countless women on their reproductive choices. Her passion surrounding a woman's right to choose led her to become a spokesperson for Planned Parenthood, fighting to enact legislation for the cause she so deeply believed in. Until the day she saw something that changed everything.

Brian Owens was once a prominent professor of quantum mechanics until an accident stripped him of his credentials; he now teaches at a community college. In order to reclaim his stature, he is trying to build the world's first teleportation machine in his garage at night. All of this while being romantically pursued by one of the art professors at the college, avoiding the crazy old lady next door, and being harassed by the loan sharks he borrowed money from to build his machine. But his biggest problem is he can't get his machine to work.​