Giada is a overachieving student who works to pay for college. Riccardo is a spoiled brat who answers her tutoring ad in order to improve his abysmal grades. She's shy and homely. He's handsome and brazen. As they say, opposites attract.

Arrogant, self-centered movie director Guido Contini finds himself struggling to find meaning, purpose, and a script for his latest film endeavor. With only a week left before shooting begins, he desperately searches for answers and inspiration from his wife, his mistress, his muse, and his mother.

Four intertwined stories on the joys and sorrows of love.

Paralyzed from a crash, Nicola falls for his physiotherapist Lucia. Franco and Manuela seek fertility treatment in Barcelona. Filippo and Fosco, a gay couple, plan their wedding. Ernesto, a waiter, has an affair with Spanish cook Cecilia.