The existence of mankind hangs in the balance as two warring factions of aliens do battle in Mark of the Astro Zombies. The film begins with an invasion of Earth by aliens who plan to turn human beings into zombies. They gather high-level government officials and attempt to get from them certain knowledge and information they will need. A kind race of aliens lands on Earth and decides to try and stop the evil ones from succeeding with their plans.

Escaped murderer Cal Lewis wants revenge for those responsible for him being put away. Enroute from Texas to Las Vegas he crosses paths with young TV news reporter Deidre Holland who quickly becomes his target.

Mutant hordes are sent to annihilate mankind.

An ultra-secret government weapons project is headed up by a mad scientist's grand-daughter. Her mission: recreate the demented killing machines known as Astro Zombies. It doesn't take long before the deadly mutant clones escape from Area 51 and all hell breaks loose! Elite teams of Men In Black attempt extreme damage control measures, while government officials, master criminals, and the famed Doll Squad spring into action -- creating a mess of epic proportions!