Twenty-eight years after the Rage virus outbreak, a heavily-defended island survives connected to the mainland by a single causeway. When one of the group leaves the island into the dark heart of the mainland, he discovers secrets, wonders, and horrors that have mutated not only the infected but other survivors as well.

Dr. Kelson finds himself in a shocking new relationship - with consequences that could change the world as they know it - and Spike's encounter with Jimmy Crystal becomes a nightmare he can't escape.

Taylor's hopes for a fresh start post-parole are jeopardised by cellmate Dee's arrival. As Dee takes Taylor under his wing, a vicious attack tests their bond, forcing Taylor to choose between protecting Dee and his own chances at freedom.