This musical is based on four short stories by Damon Runyon. In one tale, gambler Feet Samuels sells his body to science just as he realizes that Hortense loves him and that he would rather live than die. In another story, Harriet's parrot is killed, and she has problems dealing with her loss. Then, there is a gambler, "Regret", who has bloodhounds on his trail when he becomes a murder suspect. Finally, "The Brain" is bleeding profusely, and his friends search for a way to save his life through a blood transfusion.

Ever since Pam Cheney (Cheryl Ladd) lost her baby during labor, she has been struggling with depression. She is not only supported by her loving, but hard working husband Sean (Robert Desiderio), but also by her friends Ella (Polly Draper) and Terry Sabin (D. David Morin), who have also lost a baby at age three. One year after labor, Pam decides to finally take a proposal to adopt a toddler. Going through official agencies proves unsuccessful, partly due to Pam's age, partly due to the growing demand of adoption. She is advised to take care of an orphaned teenager instead, but Sean refuses this option.

After being discharged from the Army, Brian Flanagan moves back to Queens and takes a job in a bar run by Doug Coughlin, who teaches Brian the fine art of bar-tending. Brian quickly becomes a patron favorite with his flashy drink-mixing style, and Brian adopts his mentor's cynical philosophy on life and goes for the money.

A woman hires Rockford to discover if her father's death was homicide or suicide.

Jack Walsh tries to track down two of the top con-artists around. But they know every trick in the book and Jack has trouble bringing them back to LA and getting a $45,000 pay day reward.