“Letting Loose the Hounds” tells the story of Goody, who has lost his girlfriend, lives out of his car, and, worst of all, desperately needs to see a dentist. After a botched oral surgery, Goody wanders the streets of Boise. When a local trapper takes pity on him, the two spend the night commiserating about the terrible hand they have both been dealt.

An aging neuroscientist teams up with a group of young graduate students to prove his hypothesis that individuals with disabilities hold the key to unlocking a sixth sense before his past catches up with him.