Clips from assorted television programs, B-movies, commercials, music performances, newsreels, bloopers, satirical short films and promotional and government films of the 1950s and 1960s are intercut together to tell a single story of various creatures and societal ills attacking American cities.

When scientists exploring the Amazon River stumble on a “missing link” connecting humans and fish, they plan to capture it for later study. But the Creature has plans of his own, and has set his sights on the lead scientist's beautiful fiancée, Kay.

Giant robots from Venus invade Chicago. Stranded in the deserted city are Frank and Nora (who has recently attempted suicide). They meet a celebrating couple at a café, Vicki Harris and Jim Wilson. The quartet escape the robot patrol and take refuge in a large hotel. There, they encounter a new danger in Davis, a psychopathic killer.

A couple falls in love and agrees to meet in six months at the Empire State Building - but will it happen?

A penniless pregnant woman adopts the identity of a rich woman killed in a train crash.

Murders, with victims dying from spines broken by brute strength, erupt in the city and the killers, when encountered, walk away unharmed by police bullets which strike them. A police doctor's investigation of the deaths leads to the discovery of an army of dead criminal musclemen restored to life, remotely controlled by a vengeful former crime boss and a former Nazi scientist, from the latter's laboratory hidden in the suburbs.

Gangster Zac Cotton and his two henchmen, Mitch and Sonny, try to get a boat to get off a tropical island after a botched robbery heist.

After a nuclear attack, an unlikely group of survivors, including a geologist, a crook and his moll, and a prospector, find temporary shelter in the remote-valley home of a survivalist and his beautiful daughter, but soon have to deal with the spread of radioactivity - and its effects on animal life, including humans.

A forger steals and kills for a rare book from a library in order to make forgeries to sell to rich suckers.

An oil engineer surrounded by foul play helps an heiress bring in a well.