In the 1840s, Ramsey MacKay, the driver for the struggling Wells Fargo mail and freight company, will secure an important contract if he delivers fresh oysters to Buffalo from New York City. When he rescues Justine Pryor and her mother, who are stranded in a broken wagon on his route, he doesn't let them slow him down and gives the ladies an exhilirating ride into Buffalo. He arrives in time to obtain the contract and is then sent by company president Henry Wells to St. Louis to establish a branch office.

Singer Rose Carlton, otherwise known as 'The San Francisco Doll', accidentally kills her controlling boyfriend when he tries to prevent her from leaving. To evade the police, Rose sets sail for Nome with captain Bull Bracket. When the ship takes on another passenger, reformer Annie Alden, Carlton's life is changed forever, and she sets out to honor a deeply personal debt.

Jimmy and Mary get a group of kids together to play in a school orchestra. A huge contest between schools is coming up and they have a hard time raising money to go to Chicago for the contest.

A young lawyer is determined to identify who is murdering members of a wealthy New York publishing family.

A diver saves his best friend's life but loses his own arm in doing so. Later, unable to find work because of his missing arm, he is forced to go to work for a criminal searching for lost treasures. Meanwhile his friend, who has since become a policeman, finds himself assigned to break up the crook's operation and bring in his gang--including the man who saved his life.

Circumstance, an old flame and a mother-in-law drive a happily married couple to the verge of divorce and insanity.

After a young woman is coerced into prostitution and her brother framed for murder by an organized crime syndicate, retribution in the form of an ape visits the mobsters.

Anita, engaged to solid Don Barnes, is swept off her feet by magician Arturo. Before you can say presto, she's his wife and stage assistant on a lengthy world tour. But Anita is annoyed by Arturo's constant flirtations, and his death-defying stunts give her nightmares. And forget her plan to retire to a farmhouse. Eventually, she has had enough and disappears.

Two rival newspaper editors try to scoop each other through their different methods of integrity on reporting the news.

A detective and his bumbling sidekick join the crackdown on racketeering in '30s New York City.