Vampire Lestat awakens from his slumber and becomes a rock star. But chaos strikes when his music awakens Akasha, the vampire queen, who may not rest until she makes Lestat her new king.

An infant girl named Hannah is abducted by her grandmother Barbara Thomas. Hannah's father David Overton, convinced that Barbara is the head of a coven of witches, inaugurates a desperate nationwide search for his missing daughter. However, David may have a sinister agenda of his own, as indicated by the fact that his wife recently died under mysterious circumstances.