Father Jeremiah Jerome Montes has been asked by his old friend Father Baby to help him run the parish of Parmbil. Father Jejemon, as he’s known, has a knack for connecting with the young people of the community. But as soon as he gets there, he only encounters resistance. Father Baby’s sister Violetta doesn’t seem too keen on Father Jejemon running things. Worse yet, the ruthless businessman who owns the town has his sights on demolishing the Church in order to make way for a golf course. But Father Jejemon soldiers on, helping people out and showing them a new way to do things.

Fired from her job and evicted from her apartment, Martee (Regine Velasquez) brings herself and her asthmatic son to Zambales for a vacation. In a dilapidated resort, owned by Lance (Piolo Pascual), Martee finds work as a manager whose duties entails plans on how to increase the resort’s clientele. At first, Martee finds difficulty adjusting to the slower provincial lifestyle, but eventually she finds the laid-back pace more favorable.

Juanita barely escapes her mother-in-law's wrath. Maria also puts a curse on Juanita and one of her daughters, Julia Rose. The curse was that they will encouter a lifetime of bad luck. But Maria blesses the otehr daughter, Jenny Rose with good fortune. Series of appalling events and revelations unfold as their lives intertwine.

Dra. Baby Holmes is a veterenarian who left her long time boyfriend after she discovered he has been deceiving her. Realizing that her biological clock is ticking fast, she desperately searches for the perfect guy who will mary her. Roberto “BOY” Reye is a single fireman with a son born out of wedluck. Generous to a fault, Boy is considered a small town hero. Every time someone needs help, the entire neighbourhood runs to him. By chance, Baby saves Boy’s life and to show his gratitude, he offers her anything in return, She then asks Boy to give her a child. Boy thinks she’s just joking but Baby is dead serious. However, Boy discovered that he is beginning to love Baby and her many quirks. Unable to bear the guilt, Baby suddenly leaves him.