After the death in suspicious circumstances of Charles Baskerville, the last descendant of the lineage of the Baskervilles, Henry, returned to the old family mansion. The charismatic detective Sherlock Holmes and his faithful assistant, Dr. Watson, investigating the case, and discover the existence of a supernatural hound that in addition murderer according to history, killed many years ago Hugo Baskerville, the first of the line, and it seems that the curse stalks his descendants.

The girlfriend of the son of a rich railroad tycoon, attempts to help him escape the clutches of his well-meaning, but over-bearing mother whilst encouraging her own father not to give up on his business, by instigating a staged kidnapping and black-mailing scheme.

Although Dolores Jardine's grandmother has engaged her to the wealthy young Spaniard, Pedro De Alvarez, she is determined to marry a man of her own choosing. She falls in love with novelist Richard Ferris who, although initially attracted by her beauty and Creole charm, abandons the girl when his old flame Lillian Hetherington suddenly appears. Seeking revenge, Dolores invites Richard to dinner and conceals Lillian behind a curtain. After overhearing Richard promise to marry Dolores, Lillian leaves in disgust and Dolores wanders into the woods distraught. Pedro prevents her from drowning herself and takes her to his heart.