Sarah Silverman appears before an audience in Los Angeles with several sketches, taped outside the theater, intercut into the stand-up performance. Themes include race, sex, and religion. Her comic persona is a self-centered hipster, brash and clueless about her political incorrectness. A handful of musical numbers punctuate the performance.

A graduating college student planning to drift through Central and South America has an uphill battle with his girlfriend who has other plans for his and their lives including him becoming a stock broker.

Over the course of three days Ross, a college dropout addicted to crystal-meth, encounters a variety of oddball folks - including a stripper named Nikki and her boyfriend, the local meth producer, The Cook - but all he really wants to do is hook up with his old girlfriend, Amy.

Dumped by her loser boyfriend, Erin's love life hits rock bottom when her overbearing mother places an embarrassing ad in the "personals" section of a local newspaper on her behalf. Erin's disgust turns to curiosity as she searches for the right guy in a hilarious series of disastrous dates. Meanwhile, a lonely ex-plumber named Alan clumsily searches for his dream job while narrowly missing one chance meeting with Erin after another.