Against the anxieties and fears of post-9/11 America, an Arab cab driver picks up a troubled professional woman with unexpected results.

During the course of an ordinary week in Hollywood, movie producer Ben must navigate his way through shark-infested waters as he struggles to complete his latest projects. A demanding studio boss demands extensive changes to a movie starring Sean Penn, while another chief won't greenlight a project unless star Bruce Willis shaves his beard. Meanwhile, Ben tries to reconcile with his wife and maintain a relationship with his young daughter.

In the hope of winning the woman of his dreams, Amanda, lovelorn meter-reader Roger Wadell enrolls in a secret confidence-building class. The course's title takes on much more meaning when he discovers that his egomaniacal professor Dr. P also wants the same woman. They begin a fierce rivalry that quickly spirals out of control, their pranks and insults get uglier as they try to prove who is the ultimate guy's guy.

Dating coach Alex 'Hitch' Hitchens mentors a bumbling client, Albert, who hopes to win the heart of the glamorous Allegra Cole. While Albert makes progress, Hitch faces his own romantic setbacks when proven techniques fail to work on Sara Melas, a tabloid reporter digging for dirt on Allegra Cole's love life. When Sara discovers Hitch's connection to Albert – now Allegra's boyfriend – it threatens to destroy both relationships.