Thirty-something Nick Taylor and his wife Laura have been together for ten years and things aren't going too well. She senses her biological clock is ticking away and she wants children while Nick is not as sure. Not because he does not like kids but because he feels a child could be just one responsibility too many. Nick's problem is his elderly parents.

James Bolam portrays serial killer Dr. Harold Shipman in this made-for-TV drama. The film follows the story of Shipman, a general practitioner who throughout his career is believed to have killed as many as 250 of his patients. When the high death rate of his practice was investigated, it was discovered that he had given lethal doses of diamorphine to a vast number of his patients. He was put on trial where he was convicted of 15 murders and sentenced to life imprisonment.

When Gerda Wegener asks her husband Einar to fill in as a portrait model, Einar discovers the person she's meant to be and begins living her life as Lili Elbe. Having realized her true self and with Gerda's love and support, Lili embarks on a groundbreaking journey as a transgender pioneer.

DC Lenny Milton (Winstone) is not as ambitious as his best friend and popular boss DCI Michael Love (Dunbar), but the pair are drinking partners and their wives and children are close. However, this goes very wrong over the space of 7 days, when Milton is approached by the police complaints division asking him to go undercover and investigate allegations of corruption against his friend. Milton finds this difficult at first and tries to dismiss the evidence building up. But as his suspicions begin to take shape his position appears to be in danger.