Sidney is a warm and deeply quixotic man who sends his lost love a plane ticket to New York along with a letter asking her to meet him at the top of the Empire State Building. With a vintage Polaroid camera in hand, he takes to the New York streets, stopping occasionally at tourist attractions and coffee shops. Along the way, he unexpectedly meets a distraught woman who left her boyfriend that very morning after discovering that he had been unfaithful. Like Sidney, she too is drifting around Manhattan, as she waits for a flight to take her back to San Francisco.

An American with a Japanese upbringing, Chris Kenner is a police officer assigned to the Little Tokyo section of Los Angeles. Kenner is partnered with Johnny Murata, a Japanese-American who isn't in touch with his roots. Despite their differences, both men excel at martial arts, and utilize their formidable skills when they go up against Yoshida, a vicious yakuza drug dealer with ties to Kenner's past.

After a car crash sends repressed cartoonist Stu into a coma, he and the mischievous Monkeybone, his hilarious alter-ego, wake up in a wacked-out waystation for lost souls. When Monkeybone takes over Stu's body and escapes to wreak havoc on the real world, Stu has to find a way to stop him before his sister pulls the plug on reality forever!

Molly McKay is a profoundly autistic twenty-something woman who has lived in an institution from a young age following her parents' death in a car accident. When the institution must close due to budget cuts, Molly is left in the care of her neurotypical, older brother, Buck McKay, an advertising executive and perennial bachelor. Buck forces her to undergo an experimental medical treatment, with unexpectedly drastic results.

Donnie is a bartender who does not want to get involved but is unwillingly recruited into illegal activities at his sinister boss Jack's bar. Meanwhile a mysterious and angry man bent on revenging his father's death has plans of his own for Jack. Donnie soon finds himself wanted by the police, unable to find his girlfriend and left holding the bag.