Nene Raju Nene Mantri is the story of Radha Jogendra and the love of his life, Radha. His whole world revolves around her and he can go to any lengths to make her happy. But what happens when such profound love takes the shape of cavernous ambition?

Siva, a carefree young man working in a courier company, falls in love with Shruthi, a radio jockey. However, they share a love-hate relationship after Siva lies to her.