Chalte Chalte is a Telugu Romantic Action entertainer. Santhosh (Vishwadev Rachakonda) is a taxi driver who meets Shruthi (Priyanka Jain) during one of his journeys. The couple falls in love with each other and even their parents approve of their love. As time passes by, Shruthi starts hating Santhosh all of a sudden. The twists and turns form the crux of the story.

Ramana falls in love with Sulochana but their relationship fails to materialize due to which he decides to end his life. He then meets a soul that communicates with him to make him realize the importance of life over love.

It follows the story of four friends who face the wrath of a powerful man after their actions inadvertently result in a loss of face for him. They must now fight back against him for survival.