Fowl-mouthed villain Turkie carves through the likes of a rapping grandma, a mindless puppet, a wig-wearing inventor, a bisexual space worm, and their equally ridiculous friends on his quest to recover the last copy of "ThanksKilling 2". Also known as "Turkeys, In, Space!".

During a mission to colonize an alien planet, Officer Emma Fremont discovers that her crew have had their memories of Earth and their families erased. Determined to keep her own memories of her son and husband intact, Emma must fight back against her brainwashed crew.