The film is set in Reggio Calabria in the late eighties, when bribes are everywhere and the power of the city is in the hands of two bosses: Saro Lodato and Cocò Raffati.

Army colonel Gabriele Moresco and twelve of his soldiers occupy a hospital in Sicily, Italy, taking every patient and doctor as hostages and giving an ultimatum to the government: if they won't admit their role in hiding proof of the use of depleted uranium in the Balkan Wars and the subsequent countless cases of cancer among Italian soldiers in 56 hours, all the hostages will be killed. Negotiator Paolo Manfredi is called to save the hostages, not knowing that his wife and daughter are among them.

Angelo Roncalli, born in Sotto Il Monte in 1881, is known for his profound spirituality as well as his extraordinary goodness from the young years of his life. When he feels a need to serve God, Angelo goes to study theology in Bergamo, and in Apollinare School (Rome) and becomes a priest. During his studies, he gets to know his two dearest friends, Mattia and Nicola. Very soon, most people see marvelous talents in him, including his wide knowledge and a constant readiness for sacrifice. The Holy See makes him go further to bishop and cardinal, and the Holy Father sends him to various places as a representative of the Church. When Pius XII dies on October, the 9th, 1958, 77 year-old Angelo goes to Rome, to conclave to choose a new pope. However, this time, it is him who hears gentle words of Jesus "Tu es Petrus!" ("You are Peter!") and from October, the 28th leads the church as pope John XXIII