In the shock of a separation, Louis decides to question his relations with his exe, Isabelle, and with the other women of his life. The worst thing is that they all want to stay her friends. His friends and colleagues tell him he's too nice, he's not normal. Robert, a musician friend, suggests that he undertake a small exercise program: "How to become an asshole and finally please women". In parallel, Louis tries to advance his musical projects.

Philippe, an opera composer in search of inspiration, is forced to take in Simone, his rebellious, eccentric niece whose best friend is a skunk. Despite their diametrically opposed personalities, Philippe and Simone quickly discover that they may need each other more than they first thought.

Deeply affected by a series of unlikely and violent events in his youth, a solitary man has a fortuitous encounter.