During the summer of 1981, a group of friends in New York are completely unprepared for the onslaught of AIDS. What starts as a rumor about a mysterious "gay cancer" soon turns into a major crisis as, one by one, some of the friends begin to fall ill, leaving the others to panic about who will be next. As death takes its toll, the lives of these friends are forever redefined by an unconditional display of love, hope and courage.

As played out by a theatre troupe, the last days of Jesus Christ are depicted from the perspective of Judas Iscariot, his betrayer. As Jesus' following increases, Judas begins to worry that Jesus is falling for his own hype, forgetting the principles of his teachings and growing too close to the prostitute Mary Magdalene.

After agreeing to meet an obscene caller at a bar, a young New York reporter witnesses a murder and becomes an unwilling player in a dangerous game of cat-and-mouse.