After a quarter-century of political denial and social stigma, of stunning scientific breakthroughs, bitter policy battles and inadequate prevention campaigns, HIV/AIDS continues to spread rapidly throughout much of the world. Through interviews with AIDS researchers, world leaders, activists, and patients, FRONTLINE investigates the science, politics, and human cost of this fateful disease and asks: What are the lessons of the past, and what can be done to stop AIDS?

In New York City, a distraught activist confronts the mayor with a story of a friend who languished on a cot in an emergency room hallway for nine days, only to die 48 hours after leaving the hospital. In 1988, thousands of activists hold the Food and Drug Administration under siege, demanding speedier drug approval. In 1990 AIDS activists converge on the National Institute of Health, calling for a more equitable clinical trial system and expanded research into new drugs and treatment. Voices From the Front, the first feature-length documentary on AIDS activism in America, makes clear the emotional and political effects of community activism using the voices of those directly engaged. It is a powerful distillation of pictures and words from events organized to change public consciousness, expose the failure of the health care systems, and challenge government inaction and neglect concerning AIDS.

This film powerfully documents New York City's gay community's response to the AIDS crisis as they are forced to organize themselves after the government's failure to stem the epidemic. Activists who are interviewed include playwrite Larry Kramer, People With AIDS Coalition co-founder Michael Callen (who died of AIDS in 1994), New York filmmaker and journalist Phil Zwickler, as well as representatives from ACT-UP, Queer Nation and the Gay Men's Health Crisis.

Two teenage Mexican-American loners in 1987 El Paso explore a new, unusual friendship and the difficult road to self-discovery.

A story of two coalitions – ACT UP and TAG (Treatment Action Group) – whose activism and innovation turned AIDS from a death sentence into a manageable condition. Despite having no scientific training, these self-made activists infiltrated the pharmaceutical industry and helped identify promising new drugs, moving them from experimental trials to patients in record time.

The Plague (The Story of AIDS) is a rich documentary that recounts the origins of AIDS.