After years of rotting in Joliet, Les, a wrongfully imprisoned street legend known as "The Ghoul", is released into a mad search through Chicago's back alleys for the man who slaughtered his mother and robbed him of his soul. Aided by mysterious benefactors, he must delve beneath the city into a modern labyrinth of gutters whose tendrils have grown deep while he was gone. What unfolds is a desperate tale of brute force tragedy set in the supernatural underworld of Chicago, where heroes are reduced to horror-shows, villains dream of their own demise, and good and evil prove to be antiquated concepts.

Five college friends venture out on a road trip. A detour to Lisa's Uncle Marty's house leads them into the Galloway Forest which is known for mysterious disappearances and rumors of cannibalism. As Lisa experiences bizarre visions, she wonders about her darkest family secrets. The mysterious Uncle Marty has a taste for beauty and blood and nothing is as it seems as the friends become engulfed in his twisted world.

Fourteen-year–old Megan and her best friend Amy spend a lot of time on the internet, posting videos of themselves and chatting with guys online. One night Megan chats with a guy named Josh who convinces her to meet him for a date. The next day, Megan is missing—forever. Based on actual cases of child abduction.

Still guilt-ridden over the accident that took his family's lives, Eric Norris discovers that his body is host to a parasite from another world. Except, it is more than a parasite: it carries his DNA.