An evil force is awakened in downtown Athens transforming the unsuspecting citizens into raving zombies. The few survivors will have to fight hard for their lives. To the death.

A lawyer, who represents the German government against the Greek reparation claims for Nazi crimes in World War II, travels to Greece and meets one of the remaining survivors of the Kalavryta massacre that took place in 1943.

A 64-year-old mother is asked to decide whether to donate the organs of her 27-year-old brain-dead son to the man who caused his death in their car accident.

The story begins at the end of the first Kako movie. The survivors meet up with a group of other barricaded survivors and must take care of the zombies as well as other random Greeks that have taken advantage of the chaos, while shooting random moving targets (zombie or not). Throughout we take small flashback visits into ancient Greece where the zombie apocalypse has also happened and we learn how they faced them.