The Wixarika culture (or Huichol) originates from the Mexican states of Jalisco, Nayarit, and Durango where more than 50,000 Huicholes currently live and practice their indigenous traditions. A group of huicholes wants a film made that portrays their religious and social customs, as they feel it is vital to preserve their culture for new generations. The huicholes are pilgrims, deer hunters, and they eat peyote. Every year, the Huicholes embark on pilgrimages from the mountain ranges in Jalisco to places like the Wirikuta Desert in San Luis Potosí and to the Aramara Sea along the coast of San Blas, Nayarit. The filmmakers were extended the rare opportunity to follow the Huicholes from San Jose and Tesorero on their travels and document their daily lives over a two-year period.

The two largest ranches in a small town are operated entirely by women, because their menfolk have all emigrated. Seceral of the younger women have boyfriend troubles, and all the women band together to vote their own representative into City Hall as Mayor.