Dr. Ralph Snyder and Dr. Frank Blake open an office together but soon split over a rivalry for nightclub singer Diana Wayne and a difference over ethics.

Pete Grant controls the town of Pecos and it's Mayor and Marshal. When Jimmy, Denny, and Lasses arrive they soon find themselves in trouble. Already suspected of murder, Jimmy and Denny catch two of the three men that rob the Express Office only to find themselves framed for the robbery. Posing as a woman, Lasses breaks them out and they head after the third man who is the one that can clear them.

Aided by musicians at the Grand Ole Opry, a small-town mayor in the Ozarks takes on a group of crooked politicians.

Boston pharmacist Tom Craig comes to Sacramento, where he runs afoul of local political boss Britt Dawson, who exacts protection payment from the citizenry. Dawson frames Craig with poisoned medicine, but Craig redeems himself during a Gold Rush epidemic.

Linda Wadsworth rebels against her millionaire grandfather, J. H. Wadsworth, and runs away from home. Unknown to Mr. Wadsworth, she gets a job at one of his many five-and-ten-cents stores as a clerk.