A biologist from London goes to Amazonia to study the local flora. There she meets three other scientists from different nationalities and backgrounds. They advise her not to go near the Autana, a mountain regarded sacred by the local tribes, without a guide. She will do exactly the contrary.

El Cholo, a Peruvian taxi driver, flees from justice in his country and comes to Venezuela in search for a better future. After running into a gang of con-men who leave him penniless, he meets a peculiar group of Latin Americans who work for a gangster known as The Russian as hitmen. El Cholo is quickly trapped in a world of blood and ambition that makes him realize the true cost of life and death.

The film is made up of two stories: In Block 1 the story of Manuel, a lonely and gray man, whose attitude distances him from all those around him, even from his own son. In the midst of routine and alcohol, the hope of a new love arises. This is how Norma, a bar bartender, enters his life without realizing it. In Block 2, the Aristiguetas, an upper-class Venezuelan family, have moved, economically less due to the failed decisions of their father. Alejandra, the oldest of the Aristigueta children, has lived in New York for some years, ignoring the reality of her family and her country. While for Alejandra the trip back to Venezuela becomes an encounter with herself, assuming control of her family's destiny, her brother Francisco explores life in the alleys of the neighborhood.